Table 1 Transplantation of HLCs into ALF rat model.

From: Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with Endothelial Cells

 

Survival to 14 days

Mean survival

Average human albumin in rat serum

Human albumin 3 days after transplant

Human albumin 14 days after transplant

hiPSC-EB-HLC only (n = 9)

66.7% (4/6)

11.0 ± 4.4

2.6 ± 0.24 ng/ml

50.0% (4/8)

0% (0/6)

hiPSC-EB-HLC + EC (n = 9)

66.7% (6/9)

11.2 ± 4.2

14 ± 2.08 ng/ml

50.0% (3/6)

50.0% (2/4)

Healthy Control (n = 3)

100% (3/3)

14.0

0

0% (0/3)

0% (0/3)

Medium Control (n = 7)

14.4% (1/7)

5.4 ± 4.5

0

0% (0/7)

0% (0/1)

  1. During the 14 days post-transplantation observation period, there was a similar trend between the two conditions hiPSC-EB-HLCs and hiPSC-EB + EC-HLCs, and did not reach statistical significance (11.0 ± 4.4 vs. 11.2 ± 4.2 days respectively, p = 0.5802). An average of the 14 days post-transplantation human albumin that was detected in the serum of the survived animals receiving hiPSC-EB + EC-HLCs showed a greater amount (14 ± 2.08) when compared with the ones receiving the hiPSC-EB-HLCs (2.6 ± 0.24). During the 14 days post-transplantation, human albumin was detected in 50% of the rats at 3 days post-transplantation, while at 14 days post-transplantation only 50% of the rats transplanted with hiPSC-EB + EC-HLCs showed human albumin presence.
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