Figure 4
From: Loss of MafA and MafB expression promotes islet inflammation
MafA is expressed in TEC and T cells. (A–C) MafA expression in 2 months old (A) lymph nodes, (B) bone marrow, and (C) in postnatal day (P) 7 thymus. (D–F) MafA expression was predominantly detected in sorted P0,5 (D) wt TEC and (E) wt CD3+ thymocytes with reduction observed in the Maf mutants whereas no clear expression and reduction was detected in (F) dendritic cells. Results are shown as mean ± SEM from 3–6 mice/genotype and data are represented from 3 independent experiments. (G,H) Islet autoantigens Insulin2 and G6pc2 expression were assessed in P7 wt and Maf mutant thymus. Graphs are shown as mean ± SEM with 4 mice/genotype and data are represented from 2 independent experiments. Data are analyzed with one-way ANOVA Tukey’s multiple comparison test (one way ANOVA) with *P value ≤ 0.05, **P value ≤ 0.01, ***P ≤ 0.001 and ****P ≤ 0.0001 considered significant.
