Figure 4 | Scientific Reports

Figure 4

From: Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody

Figure 4

RN2N antibody formats show similar brain distribution following ultrasound treatment of a volume comprising the hippocampus. (A) Alexa Fluor 647-conjugated RN2N fluorescent signal after a sonication targeting the hippocampus. (B) Co-localization of the RN2N fluorescence with endogenous mouse IgG (mIgG) in the targeted hippocampus. (C) Calculation of the area distribution of RN2N and endogenous mouse IgG revealed no significant difference between the different sized RN2N antibodies compared to mouse IgG. (n = 3, mean ± SEM; student t-test).

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