Table 1 Comparison of LPL levels in CSF between LSS patients and controls.

From: Lysophosphatidic acids and their substrate lysophospholipids in cerebrospinal fluid as objective biomarkers for evaluating the severity of lumbar spinal stenosis

 

LSS (n = 28)

Controls (n = 15)

p-value

LPA

Total

0.10 [0.067; 0.18]

0.034 [0.025; 0.049]

*0.001

16:0

0.059 [0.043; 0.105]

0.021 [0.013; 0.031]

*0.01

18:0

0.0056 [0.0033; 0.0081]

0.0018 [0.0007; 0.0024]

*0.032

18:1

0.025 [0.012; 0.049]

0.0071 [0.0042; 0.0084]

*0.0007

18:2

0.0045 [0.00069; 0.028]

0.00095 [0.00028; 0.0015]

*0.017

20:4

0.0027 [0.00062; 0.0077]

0.00038 [0.00025; 0.0017]

*0.018

22:6

0.00042 [0.00020; 0.0016]

0 [0; 0]

*0.026

LPC

Total

0.0054 [0.0038; 0.010]

0.0013 [0.0012; 0.0029]

*0.008

14:0

0.00011 [0.000093; 0.00012]

0.000071 [0.000066; 0.000096]

*0.0003

16:0

0.0017 [0.0012; 0.0037]

0.00043 [0.00033; 0.00091]

*0.0027

16:1

0.000044 [0.000033; 0.000069]

1.4e-6 [3.8e-7; 0.000016]

*<0.0001

18:0

0.0013 [0.00092; 0.0020]

0.00067 [0.00062; 0.00071]

*0.0044

18:1

0.0014 [0.0010; 0.0021]

0.00013 [0.000089; 0.00068]

*<0.0001

18:2

0.00041 [0.00023; 0.0010]

0.000029 [0.000017; 0.00012]

*0.0009

20:4

0.00023 [0.00016; 0.00044]

0.000014 [6.5e-6; 0.00011]

*<0.0001

20:5

0.000021 [9.5e-6; 0.000053]

0 [0; 4.0e-7]

*0.0088

22:6

0.00015 [0.000085; 0.00029]

5.4e-6 [2.9e-6; 0.000053]

*0.0002

LPI

18:0

0.0018 [0.00061; 0.0043]

0 [0; 0.00021]

*0.02

  1. Data are expressed as median value [25 percentile, 75 percentile], *p < 0.05.
  2. LSS, lumbar spinal stenosis; LPA, lysophosphatidic acid; LPC, lysophosphatidylcholine; LPI, lysophosphatidylinositol; LPL, Lysophospholipid; CSF, cerebrospinal fluid.
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