Table 3 Comparison of LPL levels in CSF between severe and mild group with NPSI (paresthesia/dysesthesia subscore) in the LSS patients.

From: Lysophosphatidic acids and their substrate lysophospholipids in cerebrospinal fluid as objective biomarkers for evaluating the severity of lumbar spinal stenosis

 

NPSI (Paresthesia/Dysesthesia subscore)

Severe (n = 14)

Mild (n = 14)

p-value

LPA

Total

0.12 [0.064; 0.29]

0.094 [0.070; 0.14]

0.095

16:0

0.076 [0.041; 0.15]

0.054 [0.048; 0.076]

0.2

18:0

0.0058 [0.0034; 0.0091]

0.0047 [0.0031; 0.0078]

0.42

18:1

0.031 [0.012; 0.066]

0.021 [0.013; 0.031]

0.091

18:2

0.014 [0.00058; 0.036]

0.0041 [0.00095; 0.0075]

0.088

20:4

0.0060 [0.00054; 0.015]

0.0021 [0.00075; 0.0035]

*0.016

22:6

0.00025 [0.00018; 0.0033]

0.00060 [0.00030; 0.0016]

0.33

LPC

Total

0.0086 [0.0045; 0.019]

0.0040 [0.0038; 0.0061]

*0.006

14:0

0.00011 [0.000094; 0.00016]

0.00010 [0.000092; 0.00011]

*0.021

16:0

0.0029 [0.0014; 0.0076]

0.0013 [0.0012; 0.0020]

*0.007

16:1

0.000065 [0.000035; 0.00014]

0.000042 [0.000032; 0.000052]

*0.015

18:0

0.0018 [0.00097; 0.0042]

0.00099 [0.00091; 0.0014]

*0.009

18:1

0.0018 [0.0011; 0.0032]

0.0011 [0.00099; 0.0016]

*0.008

18:2

0.00088 [0.00031; 0.0017]

0.00036 [0.00022; 0.00055]

*0.008

20:4

0.00037 [0.00018; 0.00070]

0.00018 [0.00015; 0.00029]

*0.007

20:5

0.000035 [0.000013; 0.00011]

0.000016 [7.7e-6; 0.000029]

0.055

22:6

0.00025 [0.000089; 0.00048]

0.00011 [0.000084; 0.00016]

*0.008

LPI

18:0

0.0028 [0.00033; 0.016]

0.0011 [0.00073; 0.0024]

0.051

  1. Data are expressed as median value [25 percentile, 75 percentile], *p < 0.05.
  2. NPSI, Neuropathic Pain Symptom Inventory; LPA, lysophosphatidic acid; LPC, lysophosphatidylcholine; LPI, lysophosphatidylinositol; LPL, Lysophospholipid; CSF, cerebrospinal fluid; LSS, lumbar spinal stenosis.