Table 4 Comparison of LPL levels in CSF between severe and mild group with ZCQ in the LSS patients.

From: Lysophosphatidic acids and their substrate lysophospholipids in cerebrospinal fluid as objective biomarkers for evaluating the severity of lumbar spinal stenosis

 

ZCQ

Severe (n = 14)

Mild (n = 14)

p-value

LPA

Total

0.13 [0.090; 0.29]

0.075 [0.057; 0.16]

*0.037

16:0

0.06 [0.05; 0.15]

0.051 [0.038; 0.098]

0.17

18:0

0.0055 [0.0033; 0.0091]

0.0056 [0.0025; 0.0078]

0.41

18:1

0.028 [0.024; 0.066]

0.013 [0.0099; 0.037]

*0.031

18:2

0.027 [0.0029; 0.036]

0.0022 [0.00044; 0.0050]

*0.004

20:4

0.0050 [0.0011; 0.015]

0.0011 [0.00045; 0.0030]

*0.016

22:6

0.0016 [0.00022; 0.0049]

0.00032 [0.00018; 0.00065]

*0.016

LPC

Total

0.0064 [0.0047; 0.019]

0.0040 [0.0033; 0.0059]

*0.012

14:0

0.00011 [0.00010; 0.00016]

0.000097 [0.000092; 0.00011]

*0.049

16:0

0.0023 [0.0014; 0.0076]

0.0013 [0.0010; 0.0018]

*0.013

16:1

0.000057 [0.000042; 0.00014]

0.000035 [0.000031; 0.000059]

*0.019

18:0

0.0015 [0.0012; 0.0042]

0.00097 [0.00088; 0.0014]

*0.013

18:1

0.0015 [0.0011; 0.0032]

0.0011 [0.00094; 0.0016]

*0.021

18:2

0.00065 [0.00033; 0.0016]

0.00034 [0.00019; 0.00043]

*0.017

20:4

0.0015 [0.0011; 0.0032]

0.00018 [0.00015; 0.00029]

*0.04

20:5

0.00065 [0.00033; 0.0016]

0.000012 [6.4e-6; 0.000026]

*0.02

22:6

0.00029 [0.00019; 0.00066]

0.000089 [0.000080; 0.00019]

*0.0097

LPI

18:0

0.0023 [0.00082; 0.016]

0.0015 [0.00041; 0.0029]

0.073

  1. Data are expressed as median value [25 percentile, 75 percentile], *p < 0.05.
  2. ZCQ, Zurich Claudication Questionnaire; LPA, lysophosphatidic acid; LPC, lysophosphatidylcholine; LPI, lysophosphatidylinositol; LPL, Lysophospholipid; CSF, cerebrospinal fluid; LSS, lumbar spinal stenosis.
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