Table 5 Comparison of LPL levels in CSF between severe and mild group with morphological study in the LSS patients.

From: Lysophosphatidic acids and their substrate lysophospholipids in cerebrospinal fluid as objective biomarkers for evaluating the severity of lumbar spinal stenosis

 

Radiography

Severe (n = 18)

Mild (n = 10)

p-value

LPA

Total

0.14 [0.090; 0.29]

0.063 [0.043; 0.092]

*0.0049

16:0

0.091 [0.051; 0.15]

0.045 [0.031; 0.057]

*0.007

18:0

0.0072 [0.0039; 0.0091]

0.0033 [0.0022; 0.0055]

*0.03

18:1

0.035 [0.024; 0.059]

0.013 [0.0054; 0.021]

*0.004

18:2

0.0065 [0.0023; 0.034]

0.0012 [0.00044; 0.0075]

0.096

20:4

0.0043 [0.0013; 0.012]

0.00052 [0.00037; 0.0028]

*0.018

22:6

0.00060 [0.00022; 0.0025]

0.00033 [0.00017; 0.00078]

0.31

LPC

Total

0.0064 [0.0040; 0.018]

0.0040 [0.0032; 0.0052]

*0.02

14:0

0.00011 [0.00011; 0.00015]

0.000093 [0.000091; 0.00010]

*0.018

16:0

0.0021 [0.0012; 0.0070]

0.0013 [0.0010; 0.0017]

*0.028

16:1

0.000061 [0.000041; 0.00014]

0.000035 [0.000030; 0.000043]

*0.02

18:0

0.0015 [0.00097; 0.0039]

0.00097 [0.00087; 0.0012]

*0.025

18:1

0.0016 [0.0011; 0.0030]

0.0011 [0.00091; 0.0013]

*0.015

18:2

0.00065 [0.00033; 0.0015]

0.00029 [0.00019; 0.00044]

*0.022

20:4

0.00029 [0.00016; 0.00066]

0.00018 [0.00015; 0.00021]

*0.014

20:5

0.000028 [0.000015; 0.000066]

9.7e-6 [4.5e-6; 0.000036]

0.13

22:6

0.00018 [0.00011; 0.00036]

0.000089 [0.000078; 0.00014]

*0.028

LPI

18:0

0.0029 [0.0017; 0.011]

0.00067 [0.00031; 0.0012]

*0.03

  1. Data are expressed as median value [25 percentile, 75 percentile], *p < 0.05.
  2. LPA, lysophosphatidic acid; LPC, lysophosphatidylcholine; LPI, lysophosphatidylinositol; LPL, Lysophospholipid; CSF, cerebrospinal fluid; LSS, lumbar spinal stenosis.
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