Table 2 Potency and antagonistic index (AI) of typical MTNR antagonist in mammals for medaka MTNRs with EC90 melatonin.
From: Vertebrates originally possess four functional subtypes of G protein-coupled melatonin receptor
Ligand | MTNR1a | MTNR1b | MTNR1c | MTNR1a-like | ||||
|---|---|---|---|---|---|---|---|---|
Potency (M) | AI (%) | Potency (M) | AI (%) | Potency (M) | AI (%) | Potency (M) | AI (%) | |
4P-PDOT | NC | ND | 1.9 ± 0.22 × 10−7 | 68.3 ± 8.0 | NC | 59.8 ± 4.9 | NC | ND |
Luzindole | NC | ND | NC | ND | NC | ND | NC | ND |
