Figure 5
From: PSD-95 deficiency disrupts PFC-associated function and behavior during neurodevelopment
PSD-95−/− mice are socially impaired and display a lack of social novelty and exploration. (A) Diagram depicting a subject mouse in the center chamber of a 3-chamber apparatus that includes a novel mouse in one chamber and a novel object in the other chamber comparing PSD-95−/−mice and control mice at postnatal day 35. (B) Summary graphs show time (seconds) spent in each chamber (novel object, center, novel mouse). The time spent in chamber, ANOVA, F(2,57) = 6.694, p = 0.002. (C) The time spent sniffing, ANOVA, F(1,38) = 6.192, p = 0.017 with paired t-tests CON, KO, p = 0.347. (D) Social preference was calculated by the time spent sniffing stranger mouse divided by total time spent sniffing × 100 (% ± s.e.m.), p = 0.047. (E) Diagram representing a subject mouse in the center chamber, and familiar mouse and intruder mouse in side chambers. (F) Summary graphs show time (seconds) spent in each chamber (familiar mouse, center, intruder mouse). The time spent in chamber, ANOVA, F(2,57) = 6.556, p = 0.003. (G) The time spent sniffing, ANOVA, F(1, 38) = 3.413, p = 0.012; paired t-tests CON, p = 0.033, KO, p = 0.792. (H) Social preference was calculated. p = 0.036. *p < 0.05, **p < 0.01, n.s., not significant.
