Figure 2
From: Dysfunctional MDR-1 disrupts mitochondrial homeostasis in the oocyte and ovary
TCA metabolite over-accumulation indicates mitochondrial dysfunction in mdr1a mutant ovaries. (A) mdr1a mutant ovaries have over accumulation of metabolites in the Krebs Cycle. (B) Ovaries from mdr1a mutant and wild type mice were analyzed for polar and non-polar metabolites. Thirteen metabolites showed significant over-accumulation in mdr1a mutant mouse versus wild type, which are indicated in purple above. Nine of the thirteen were associated with the TCA cycle. The other metabolites were adenine, GMP, dTMP and CMP.
