Figure 6
From: Dysfunctional MDR-1 disrupts mitochondrial homeostasis in the oocyte and ovary
mdr1a mutant animals produce more oocytes at ovulation, but do not give birth to more pups. (A) mdr1a mutant mice produced statistically more oocytes at natural ovulation (n = 4, p = 0.0340), and upon superovulation (n = 3, p = 0.0436). (B) Each bar section represents one female mouse (Mouse A, B, C or D) that gave birth to three successive litters. Pup counts across these three litters were averaged for each mouse. The average number of pups born to the mice in each group weren’t statistically different. (C,D) mdr1a mutant male pups, born to mutant female and mutant male pairs, weigh more than control and mutant female pups. Pups were weighed at (C) weaning age (21 days) and then again at (D) 6 weeks (42 days). (E) Ovaries of virgin 2 month mdr1a mutant mice were significantly larger than ovaries of virgin wild type mice of exactly the same age. (F) Ovaries of virgin superovulated mice of the same age exhibited no difference in size.
