Table 2 Univariate and Multivariable Recurrence-Free Survival Analysis for Primary Patients in MSKCC data set.

From: The Homeobox gene, HOXB13, Regulates a Mitotic Protein-Kinase Interaction Network in Metastatic Prostate Cancers

Univariate Analysis

Overall Variable P Value

Multivariable Analysis

Variable

Reference

Level

HR (95% CI)

Level Comparison P Value

HR (95% CI)

Level Comparison P Value

Overall Variable P Value

Age at diagnosis (years)

<64 Years

> = 64 Year

1.59 (0.69,3.65)

0.2748

0.2748

   

Gleason Score

5–6

7

3.92 (0.89,17.25)

0.0709

<0.0001

2.37 (0.52, 10.78)

0.2627

<0.0001

 

5–6

8–10

31.19 (6.83,142.36)

<0.0001

 

19.5 (4, 95.09)

0.0002

 

Clinical Tumor Stage

T1C

T2,T2A,T2B,T2C

0.69 (0.29,1.63)

0.3994

0.0018

   
 

T1C

T3,T3A,T3B,T3C

6 (1.96,18.43)

0.0017

    

Lymph node involvement

Normal_N0

Abnormal_N1

8.67 (3.2,23.46)

<0.0001

<0.0001

10.65 (3.18, 35.67)

0.0001

0.0001

Margin Status

Negative

Positive

2.7 (1.26,5.79)

0.0106

0.0106

   

PSA at Diagnosis

<10

> = 10

2.25 (0.98,5.17)

0.0557

0.0557

   

MKI67

Low

High

2.05 (0.95,4.43)

0.0663

0.0663

   

NEK2

Low

High

2.59 (1.16,5.78)

0.0198

0.0198

   

AURKA

Low

High

0.81 (0.37,1.74)

0.5810

0.5810

   

BUB1

Low

High

3.02 (1.35,6.73)

0.0069

0.0069

3.94 (1.58, 9.86)

0.0034

0.0034

CIT

Low

High

1.62 (0.76,3.45)

0.2117

0.2117

   

HSPB8

Low

High

0.5 (0.23,1.07)

0.0725

0.0725

   

NCAPG

Low

High

2.54 (1.16,5.56)

0.0198

0.0198

   

TRPM8

Low

High

1.52 (0.69,3.32)

0.2963

0.2963

   

NUF2

Low

High

1.59 (0.75,3.41)

0.2294

0.2294

   
  1. Backwards Selection at removal alpha = 0.05.
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