Table 2 Fatty acid profiles in plasma of control (C) and in utero exposed (E) F1 adult pregnant dams at 28dpc (% of total fatty acids).

From: Effects of first-generation in utero exposure to diesel engine exhaust on second-generation placental function, fatty acid profiles and foetal metabolism in rabbits: preliminary results

Variable

Number of dams

Median [Q1; Q3]

Fully adjusted linear model

C

E

Control

Exposed

β value

CI

p-value

C16:0 (PA)

3

9

29.1 [28.5; 30.1]

31.8 [30.4; 32.8]

2.55

[0.53; 4.57]

0.067

C16:1n-7

3

9

10.4 [8.2; 11.5]

6.4 [6.1; 8.2]

−3.15

[−4.98; −1.31]

0.027*

Total C16:1

3

9

10.9 [8.6; 11.9]

7.1 [6.6; 8.6]

−3.10

[−4.91; −1.28]

0.028*

C18:0 (SA)

3

9

8.0 [6.0; 9.2]

10.0 [8.7; 12.7]

3.73

[−0.90; 8.36]

0.186

Total C18:1

3

9

25.2 [25.0; 28.8]

25.4 [24.2; 29.5]

−1.03

[−8.21; 6.15]

0.791

C18:2 n-6 (LA)

3

9

17.7 [16.9; 17.9]

16.2 [15.4; 17.3]

−1.25

[−2.44; −0.06]

0.106

C18:3 n-3 (ALA)

3

9

2.8 [2.5; 3.3]

1.8 [1. 6; 2.0]

−1.22

[−1.85; −0.59]

0.019*

C20:4 n-6 (AA)

3

9

1.5 [0.9; 1.6]

1.0 [0.8; 1.7]

−0.06

[−0.84; 0.72]

0.892

C20:5 n-3 (EPA)

3

9

0.02 [0.00; 0.04]

0.04 [0.02; 0.37]

0.18

[−0.34; 0.71]

0.529

C22:4 n-6

3

9

0.04 [0.04; 0.11]

0.04 [0.03; 0.06]

−0.01

[−0.08; 0.06]

0.794

C22:5 n-6

3

9

0.08 [0.00; 0.08]

0.06 [0.05; 0.11]

0.04

[−0.05; 0.14]

0.397

C22:5 n-3 (DPA)

3

9

0.07 [0.05; 0.08]

0.05 [0.02; 0.08]

−0.01

[−0.07; 0.05]

0.710

C22:6 n-3 (DHA)

3

9

0.05 [0.04; 0.07]

0.04 [0.03; 0.06]

−0.01

[−0.05; 0.03]

0.608

Total SFA

3

9

39.9 [38.7; 40.0]

44.9 [41.5; 47.5]

6.37

[−0.98; 13.71]

0.162

Total MUFA

3

9

37.8 [36.7; 37.9]

34.6 [31.4; 37.3]

−4.04

[−10.34; 2.25]

0.272

Total n-6 PUFA

3

9

19.7 [19.4; 20.1]

18.9 [17.6; 19.3]

−1.16

[−3.05; 0.72]

0.289

Total n-3 PUFA

3

9

3.2 [2.9; 3.7]

2.3 [2.1; 2.8]

−1.11

[−2.01; −0.22]

0.068

n-6/n-3 PUFA ratio

3

9

6.4 [5.3; 6.8]

8.2 [6.6; 9.5]

2.64

[−0.59; 5.88]

0.181

PUFA/SFA ratio

3

9

0.58 [0.56; 0.60]

0.50 [0.42; 0.52]

−0.11

[−0.19; −0.03]

0.049*

DNL index

3

9

1.7 [1.6; 1.7]

1.9 [1.8; 2.1]

0.30

[0.06; 0.53]

0.070

  1. Data are expressed as Median[Q1;Q3], in % of total FA. AA: C20:4n-6, arachidonic acid; ALA: C18:3n-3, alpha-linolenic acid; CI: Confidence Interval; DHA: C22:6n-3, docosahexaenoic acid; DNL index: de novo lipogenesis (C16:0/C18:2n-6 ratio)22,23; DPA: C22:5n-3, docosapentaenoic acid; EPA: C20:5n-3, Eicosapentaenoic acid; LA: C18:2n-6, linoleic acid; MUFA: monounsaturated fatty acids; PA: C16:0, palmitic acid; PL: phospholipids; PUFA: polyunsaturated fatty acids; SA: C18:0, stearic acid; SFA: saturated fatty acids “Statistics with *P < 0.05” and **P < 0.01.
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