Figure 3
From: Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system
Association between proteasome blocking and cell death. MelJuSo-UbG76V-YFP melanoma cells were exposed to the different hit compounds for 24 hours. An IncuCyte® instrument was used to monitor cells during exposure. Examples of cells becoming YFP positive and subsequently dying are shown with yellow arrows, examples of cells not becoming positive for the reporter and surviving treatment are shown with blue arrows, and examples of YFP-negative cells that died during incubation are indicated by white arrows. Note the variable degree of survival of cells that did not become positive for the UbG76V-YFP reporter during drug exposure.
