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Figure 1

From: Dual Kit/Aur Inhibitors as Chemosensitizing Agents for the Treatment of Melanoma: Design, Synthesis, Docking Studies and Functional Investigation

Figure 1

Kinase Inhibitory Data of 1-(Substituted)phenyl-3-(4-(((5-phenyl-1H-1,2,4-triazol-3-yl)methyl)thio)phenyl)urea Derivatives, 6a–i. Data are expressed as percentage of kinase inhibition at 10 μM test compound, obtained as mean of at least three determinations. Standard error of the mean (SEM) is ≤10%. Compound 6e displayed no inhibitory activity when tested against both AurA and AurB. Compound 6g displayed no inhibitory activity when tested against AurA. Compound 6h displayed no inhibitory activity when tested against AurB. The reference compound, DP01920, was not tested against both AurB and AurC.

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