Table 2 Specificity of ryuvidine.

From: Identification of ryuvidine as a KDM5A inhibitor

Enzymes

IC50

KDM5A

0.57 ± 0.1 μMa

KDM5B

0.026 ± 0.01 μMa

KDM5C

8.73 ± 1.8 μMa

LSD1

no inhibition at 50 μMb

LSD2

no inhibition at 50 μMb

  1. Activities were measured with MALDI-TOF MS method. Ryuvidine concentration was varied from 0.21–50 µM for KDM5A and KDM5C and 0.008–50 µM for KDMA5B.
  2. aData represent n = 3; bData represent n = 9.
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