Table 1 L. monocytogenes genes deregulated in the ΔladR, ΔlstR and lltR* mutants.
locus | function | fold induction ΔladR /wt | P value |
|---|---|---|---|
upregulated in Δ ladR | |||
lmo1409 | MdrL major facilitator superfamily efflux pump | 153.8 ± 44.3 | 0.0003 |
lmo1618 | MarR family transcriptional regulator | 4.3 ± 0.4 | 0.0003 |
lmo1617 | MdrM multidrug transporter | 2.6 ± 0.8 | 0.0094 |
upregulated in Δ lstR | fold induction Δ lstR /wt | ||
lmo0421 | RodA-like rod shape-determining protein | 145.0 ± 11.3 | 2.6 × 10−5 |
lmo0423 | RNA polymerase factor sigma C | 139.3 ± 19.3 | 8.6 × 10−7 |
lmo0420 | hypothetical protein, HAD family hydrolase | 54.9 ± 10.2 | 0.0001 |
lmo0419 | hypothetical protein | 7.1 ± 1.5 | 0.0035 |
lmo2773 | putative transcription antiterminator | 2.4 ± 0.5 | 0.0035 |
lmo2050 | excinuclease ABC subunit A | 2.3 ± 0.4 | 0.0037 |
downregulated in Δ lstR | |||
lmo1597 | hypothetical protein | 0.5 ± 0.04 | 0.0083 |
lmo0416 | putative transcriptional regulator | 0.5 ± 0.01 | 0.0017 |
lmo0417 | hypothetical protein | 0.4 ± 0.02 | 0.0084 |
lmo1839 | PyrP similar to uracil permease | 0.2 ± 0.06 | 0.0074 |
upregulated in lltR * | fold induction lltR */wt | ||
lmo0599 | LltR, PadR-like transcriptional repressor | 150.6 ± 49.7 | 4.4 × 10−05 |
lmo0600 | DUF1700 containing hypothetical protein | 118.0 ± 34.3 | 0.0001 |
lmo0601 | DUF4097 containing hypothetical protein | 106.8 ± 23.8 | 4.8 × 10−5 |
lmo0602 | hypothetical protein, N-acetyltransferase domain | 12.7 ± 9.1 | 0.0011 |
lmo0954 | LiaI phage shock protein | 3.8 ± 1.1 | 0.0024 |
lmo2487 | DUF4097 containing hypothetical protein | 3.1 ± 0.7 | 0.0072 |
lmo0955 | LiaH phage shock protein | 2.6 ± 0.6 | 0.0027 |
lmo1637 | putative ABC transporter, permease protein | 2.5 ± 0.2 | 0.0003 |
lmo0047 | putative lipoprotein | 2.4 ± 0.4 | 0.0029 |
lmo1636 | putative ABC transporter, ATP binding protein | 2.4 ± 0.4 | 0.0043 |
