Figure 5
From: Large-scale Discovery of Substrates of the Human Kinome
Characteristics of serine or threonine-directed kinases. (a) Correlation between serine/threonine preference of STKs and the maximum fold-increase in their phosphorylation motifs. (b) The box plot of a ratio of multiply phosphorylated peptides identified by in vitro kinase profiling for serine-directed, threonine-directed tyrosine kinases. (c) Relationship between Ser/Thr specificity and the amino acid at the +1 position of the common sequence “DFG” in the kinase domains.
