Figure 2
From: Distribution of fitness effects of mutations obtained from a simple genetic regulatory network model
Beneficial and deleterious mutations can be represented as an exponential distribution at low system fitness. (A) Distribution of fitness effects of beneficial mutations when system fitness is 0.001fmax. The distribution is fit well by exponential distribution with an R2 value of 0.9805. (B) Distribution of fitness effects of deleterious mutations when system fitness is 0.001fmax. The distribution can be presented by exponential distribution with an R2 value of 0.9861. (C) 100 different parameter sets, corresponding to same 0.001fmax are simulated and DFE of beneficial mutations obtained as given in (A), the fitting parameter λ and goodness of fit R2 value is plotted. We note that beneficial mutations are fit well by exponential distribution irrespective of the precise location in the fitness landscape. (D) The DFE of deleterious mutations obtained from simulation of the 100 different parameter sets all with fitness 0.001fmax. The overall goodness of fit for deleterious mutations is significantly poorer compared to the beneficial mutations.
