Figure 6
From: Distribution of fitness effects of mutations obtained from a simple genetic regulatory network model
Epistatic interactions between beneficial mutations. Beneficial mutation in a specific parameter pi (x-axis) is introduced into two backgrounds: one where there is no other beneficial mutation and another where the parameter set is carrying another beneficial mutation in pj. The ratios of benefit conferred by pi in the two sets is plotted (∆f corresponds to benefit conferred by pi in the original set; and ∆f* refers to the benefit conferred in the set carrying the beneficial mutation pj). For each mutation pi, around 4000 sets carrying a distinct beneficial mutations (pj-s) are used. A ratio of more than one implies greater benefit being conferred by pi in the original set than in the presence of the beneficial mutation pj. For details on the clusters for each parameter represented on the X-axis, see Supplement Fig. 2.
