Table 2 Metabolites showing differential abundance in 1X and 5X intestinal tissue samples.

From: Acute and short-term administrations of delta-9-tetrahydrocannabinol modulate major gut metabolomic regulatory pathways in C57BL/6 mice

Metabolite Name (§)

Associated metabolic process

M/Z

1X

5X

+/−

Fold change

p-value (adj.)

+/−

Fold change

p-value (adj.)

N- Heptanoylglycine

Fatty acid metabolism

186.11

+

4.7

0.003

   

N-Decanoyl glycine

Fatty acid metabolism

228.16

+

4.8

0.04

   

2-hydroxy-6-methoxy-4-(prop-2-en-1-yl)phenyl]oxidanesulfonic acid

Unknown

259.03

+

2.1

0.01

   

Inosine

Purine metabolism

267.03

+

2.2

0.01

   

Pe-nme2(14:0/18:1(11Z))

Glycerophospholipid metabolism

716.52

−

2.3

0.0006

   

(2-Aminoethoxy)[(2R)-3-[(1Z,9Z)-octadeca-1,9-dien-1-yloxy]-2-[(9Z,12Z,15Z)-octadeca-9,12,15-trienoyloxy]propoxy]phosphinic acid

Glycerophospholipid metabolism

722.51

   

+

4.1

0.006

PE(P-16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))

Glycerophospholipid metabolism

746.51

   

+

2.5

0.02

(2-Aminoethoxy)[(2 R)-3-[(7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoyloxy]-2-[(1Z)-hexadec-1-en-1-yloxy]propoxy]phosphinic acid

Glycerophospholipid metabolism

748.53

   

+

3.1

0.0008

PG(18:0/18:2(9Z,12Z))

Glycerophospholipid metabolism

774.54

   

+

2.4

0.03

PG(18:0/18:1(9Z))

Glycerophospholipid metabolism

775.54

−

2.6

0.008

   

PS(15:0/20:0)

Glycerophospholipid metabolism

776.55

   

+

4.4

0.04

PS(15:0/22:0)

Glycerophospholipid metabolism

804.57

   

+

3.6

0.03

PA(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/24:1(15Z))

Glycerophospholipid metabolism

829.57

  

0.02

+

7.3

0.03

Palmitamide

Fatty acid biosynthesis

256.26

+

3.1

0.01

   

Palmitic acid

Fatty acid biosynthesis

257.27

+

3.0

0.01

   

5-[3,5-Bis(butan-2-yl)cyclopent-1-en-1-yl]-5-hydroxy-3-oxopentanoic acid

Fatty acid biosynthesis

311.23

+

3.7

0.002

   

1,2,4-Nonadecanetriol

Fatty acid biosynthesis

317.30

+

2.5

0.001

   

Docosanamide

Fatty acid biosynthesis

340.36

   

−

5.2

0.01

1,3-Dihydroxypropan-2-yl (5Z,8Z,11Z)-icosa-5,8,11-trienoate

Fatty acid biosynthesis

381.30

+

9.1

0.01

   

12alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid

Fatty acid biosynthesis

391.28

   

+

3.8

0.009

Pe-nme(16:0/18:1(11Z))

Glycerophospholipid metabolism

732.56

   

+

7.6

0.04

Pe-nme2(16:1(9Z)/18:1(11Z))

Glycerophospholipid metabolism

744.56

   

+

3.6

0.01

Pe-nme(18:1(9Z)/18:3(9Z,12Z,15Z))

Glycerophospholipid metabolism

754.54

   

+

7.2

0.03

PA(20:3(8Z,11Z,14Z)/20:0)

Glycerophospholipid metabolism

755.56

+

2.8

0.008

   

PC(14:0/20:0)

Glycerophospholipid metabolism

761.59

   

+

14.5

0.02

(2-{[3-(hexadecyloxy)-2-[(5E,8E,11E,14E,17E)-icosa-5,8,11,14,17-pentaenoyloxy]propyl phosphonato]oxy}ethyl)trimethylazanium

Unknown

766.57

   

+

3.9

0.03

PC(22:2(13Z,16Z)/14:1(9Z))

Glycerophospholipid metabolism

784.58

   

+

3.9

0.02

PC(22:4(7Z,10Z,13Z,16Z)/16:0)

Glycerophospholipid metabolism

810.60

   

+

2.7

0.001

PC(22:2(13Z,16Z)/16:1(9Z))

Glycerophospholipid metabolism

812.61

   

+

2.6

0.004

PC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/20:3(5Z,8Z,11Z))

Glycerophospholipid metabolism

856.58

−

2.8

0.01

+

3.0

0.002

  1. (§) Putative Metabolites were identified through interpretation of tandem MS data. Feature identities were determined using a two-step approach described previously76: (1) search of public databases including METLIN, HMDB and Mass Bank using accurate mass and a mass error window of 10 ppm and (2) comparison of tandem MS data with available spectra for four important features followed by manual interpretation.
  2. (*) The metabolic processes indicated in this column are the processes that most closely associated with the detected metabolites. This means that the detected metabolites may be an intermediate, a product or derivatives of intermediates or products of the mentioned processes. The metabolic processes were identified based on available information in HMDB, Kegg database and Lipidomics Gateway. The compounds for which we could not find any information are denoted as ‘Unknown’.
  3. (+/−) Increase/Decrease.
Back to article page