Figure 2
From: Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis
Peritoneal microRNAs during bacterial peritonitis. (A) miR-223, miR-21, miR-27a and miR-31 were measured in effluent samples from three individual patients followed over the course of a week, starting from their presentation at hospital with acute peritonitis. All levels were normalised to snRNA U6 levels and are shown as relative values compared to a corresponding post-infection sample from each patient 10–12 months after the resolution of the peritonitis episode. Infective organisms were identified by microbiological culture as Staphylococcus aureus (#142), coagulase-negative Staphylococcus (#152) and alpha-haemolytic Streptococcus (#219). (B) microRNA expression during acute peritoneal E. coli infection in C57BL/6 mice aged 8–12 weeks (n = 6), compared to mock-treated animals (PBS; n = 3). Each data point represents an individual animal; lines indicate means and standard errors. Data were analysed by two-way ANOVA and Holm-Sidak’s multiple comparisons test.
