Figure 1
(a–d) Representative 2D slices of healthy myometrium (Ctr) and pathologic (L) tissues. (a,b) Patient 1 (P1): healthy myometrium (a: P1-Ctr) and leiomyoma (b: P1-L) tissues; (c,d) Patient 2 (P2): healthy myometrium (c: P2-Ctr) and leiomyoma (d: P2-L) tissues. Morphological dissimilarities were found not only between Ctr and L samples of the same patient and between pathologic tissues of the two patients (P1-L vs. P2-L) but also between the healthy tissues of the two patients (P1-Ctr vs. P2-Ctr). (e,f) Representative 3D volumes of healthy myometrium (e: P1-Ctr) and pathologic (f: P1-L) tissues: all the tissues but the collagen phase have been made virtually transparent. The bright spots that we found in all the samples were due, most likely, to the presence of blood clots residues, not removed by washing because of the structure tortuosity.
