Table 4 List of circRNAs selected for validation with their corresponding parental gene, MREs, miRNAs, and associated miRNA function.
CircRNA | Genomic Location | Expression | Fold Change | p-value | Parental Gene | MRE | Gene Function |
---|---|---|---|---|---|---|---|
hsa_circ_0004870 | chr20:34302106-34313077 | down | 2.4 | 0.0015 | RBM39 | miR-145 | Cancer cell migration and invasion50 |
hsa_circ_0002807 | chr13:114149816-114164739 | down | 1.7 | 0.0009 | TMCO3 | miR-141 | Suppresses stem cells51 |
hsa_circ_0022383 | chr11:61605249-61615756 | down | 6.1 | 0.0244 | FADS2 | miR-124 | Inhibits invasion and proliferation52 |
hsa_circ_0003505 | chr17:20910208-20911309 | down | 1.6 | 0.0421 | USP22 | miR-124 | Inhibits invasion and proliferation52 |
hsa_circ_0088059 | chr9:114905750-114905903 | down | 2.5 | 0.0281 | SUSD1 | miR-124 | Inhibits invasion and proliferation52 |
hsa_circ_0000673 | chr16:11940357-11940700 | up | 3.5 | 0.0053 | RSL1D1 | miR-25 | Modulates invasiveness and dissemination53 |
hsa_circ_0002754 | chr8:41905895-41907225 | up | 2.3 | 0.0493 | KAT6A | miR-145 | |
hsa_circ_0001278 | chr3:31617887-31621588 | up | 1.6 | 0.0004 | STT3B | miR-205 | ERG target gene56 |
hsa_circ_0001721 | chr7:90355880-90356126 | up | 1.9 | 0.0103 | CDK14 | miR-221 | Promotes cell proliferation and represses apoptosis35 |
hsa_circ_0083092 | chr7:155471301-155473602 | up | 2.4 | 0.0051 | RBM33 | miR-125b | Tumour suppressor57 |