Figure 4
From: Keratin 17 identifies the most lethal molecular subtype of pancreatic cancer
K17 is an independent negative prognostic biomarker, at both the mRNA and IHC (protein) levels. (a) Forest plot showing the univariate analysis using Cox proportional hazards regression for K17 mRNA as a binary variable and other PDAC risk factors from combined mRNA cohorts (Moffitt et al.22 and The Cancer Genome Atlas [TCGA])23. Surgical margin status, lymph node status, pathologic stage, molecular subtype and K17 status were all negative prognostic markers with significant p-values. (b) Forest plot showing the multivariate analysis from K17 mRNA as a binary variable and other risk factors, from combined mRNA cohorts. Surgical margins, molecular subtype and K17 showed significant p-values. (c) Forest plot showing the univariate analysis using Cox proportional hazards regression for K17 as a continuous variable and other PDAC risk factors from the IHC cohort. Tumor grade, surgical margins and K17 showed significant p-values. (d) Forest plot showing the multivariate analysis from K17 as a continuous variable and other risk factors, from IHC cohort. K17 and surgical margins show significant p-values.
