Figure 4
From: Colorectal cancer cells respond differentially to autophagy inhibition in vivo
RAB21 depletion differentially affects gene expression in HCT116 and SW480 cells. (A) Clustered heatmap of the top 60 most differentially expressed genes in RAB21-depleted HCT116 and SW480 cells. (B to E) Most up/down regulated differentially expressed Reactome Gene Sets (RGS) between control and RAB21-depleted cells generated through a GSEA analysis and classified according to their normalized enrichment score NES score in HCT116 and SW480. All represented GSEA pathways had False Discovery Rate values inferior to 0.003. (F) Representative enrichment plot of RAB21-depleted SW480 cells. (G) Leading Edge analysis of the twenty most differentially upregulated pathways in RAB21-depleted SW480 cells.
