Figure 8 | Scientific Reports

Figure 8

From: Paxillin S273 Phosphorylation Regulates Adhesion Dynamics and Cell Migration through a Common Protein Complex with PAK1 and βPIX

Figure 8

Proposed model of effects of paxillin S273 phosphorylation on adhesion binding, regulation of adhesion dynamics and cell migration. (A) Protrusive region of CHO-K1 cell expressing paxillin-S273A-EGFP (cyan) and actin stained with phallodin AF594 (red) indicating actin cables interacting with the membrane distal region of adhesions. (B) Proposed model of spatial coordination of paxillin pS273 and binding to the PAK1 and βPIX through GIT1 at the membrane proximal end of adhesions in protrusive regions of the cell. The model proposes that localization of paxillin pS273 bound with PAK1 and βPIX to membrane proximal regions of the adhesion is associated with higher Rac GTPase activity, active PAK1 kinase activity, βPIX GEF activity and minimal interactions with the actin cytoskeleton.

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