Figure 7
From: Short-term CFTR inhibition reduces islet area in C57BL/6 mice
Glucose stimulated insulin secretion. Islets were isolated from animals treated with vehicle control or CFTRinh172 and exposed to 1.1 mM glucose, or 16.7 mM glucose ± 10 nM GLP-1 for 1 h. (a) Static insulin release was measured by ELISA with *p < 0.05, **p < 0.01 and ***p < 0.001 compared to either 1.1 mM or 16.7 mM glucose as indicated in the Figure (one-way ANOVA). (b) Data was adjusted for pancreatic insulin content under basal (1.1 mM) glucose conditions with ***p < 0.001 compared to corresponding control animals (t test). Data are presented as mean ± SEM (n = 8–10 for all experiments).
