Table 1 Retinal arteriolar, venular and capillary parameters at different levels of diabetic retinopathy severity.

From: Global Assessment of Retinal Arteriolar, Venular and Capillary Microcirculations Using Fundus Photographs and Optical Coherence Tomography Angiography in Diabetic Retinopathy

DR severity level

Non-severe DR (n = 29)

Severe DR (n = 20)

p-trend (No DR to Proliferative DR)a

p-value (non-severe DR vs severe DR)b

No DR (n = 9)

Mild NPDR (n = 10)

Moderate NPDR (n = 10)

Severe NPDR (n = 8)

Proliferative DR (n = 12)

Arteriolar and venular (SIVA) parameters, mean (SD)

CRAE

143.3 (23.8)

157.3 (15.3)

151.4 (20.3)

137.5 (15.1)

134.6 (17.8)

0.046

 

151.3 (19.7)

135.7 (16.4)

 

0.009

CRVE

219.9 (32.1)

220.2 (18.9)

211.9 (36.6)

213.2 (19.1)

198.1 (30.6)

0.093

 

216.9 (29.3)

204.1 (27.1)

 

0.163

AVR

0.657 (0.098)

0.715 (0.056)

0.727 (0.128)

0.645 (0.040)

0.686 (0.075)

0.454

 

0.704 (0.100)

0.669 (0.065)

 

0.123

FDt

1.368 (0.114)

1.349 (0.091)

1.398 (0.086)

1.364 (0.089)

1.300 (0.148)

0.318

 

1.373 (0.094)

1.325 (0.129)

 

0.219

FDa

1.131 (0.104)

1.151 (0.085)

1.175 (0.072)

1.126 (0.107)

1.093 (0.106)

0.324

 

1.155 (0.084)

1.106 (0.105)

 

0.150

FDv

1.192 (0.089)

1.138 (0.075)

1.206 (0.077)

1.172 (0.090)

1.134 (0.113)

0.384

 

1.179 (0.082)

1.149 (0.104)

 

0.282

Capillary (OCT-A) parameters, mean (SD)

SVP CDI

0.360 (0.021)

0.356 (0.022)

0.347 (0.009)

0.340 (0.023)

0.333 (0.010)

<0.001

 

0.354 (0.018)

0.336 (0.016)

 

0.001

DVP CDI

0.360 (0.019)

0.356 (0.025)

0.352 (0.019)

0.346 (0.021)

0.345 (0.021)

0.048

 

0.356 (0.021)

0.345 (0.020)

 

0.093

SVP FDc

1.515 (0.072)

1.581 (0.049)

1.564 (0.076)

1.546 (0.040)

1.601 (0.050)

0.059

 

1.555 (0.070)

1.579 (0.053)

 

0.290

DVP FDc

1.537 (0.090)

1.612 (0.060)

1.599 (0.070)

1.556 (0.074)

1.533 (0.125)

0.350

 

1.584 (0.078)

1.542 (0.106)

 

0.089

  1. Abbreviations: DR = diabetic retinopathy; NPDR = non-proliferative diabetic retinopathy; SIVA = Singapore I Vessel Assessment; CRAE = central retinal arteriolar equivalent; CRVE = central retinal venular equivalent; AVR = arteriole-venule ratio; FDt = total fractal dimension; FDa = arteriole fractal dimension; FDv = venule fractal dimension; OCT-A = optical coherence tomography angiography; SVP = superficial vascular plexus; CDI = capillary density index; DVP = deep vascular plexus; FDc = capillary fractal dimension.
  2. ap-trends calculated using the Wilcoxon-type test for trend.
  3. bp-values calculated using the Mann-Whitney U test.
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