Table 3 The activity (µg/ml) of propolis against wild type and miltefosine-APC12 resistant L. mexicana (C12Rx).

Propolis ID	L. mexicana wild type	L. mexicana C12Rx	Resistance Index	ttest
Propolis ID	(µg/mL)	(µg/mL)	Resistance Index	ttest
Suffolk 4, UK	1.04 ± 0.19	0.81 ± 0.15	0.78	0.40
Bulgaria 1	0.35 ± 0.03	0.29 ± 0.04	0.85	0.33
Suffolk 2, UK	0.85 ± 0.14	0.45 ± 0.03	0.53	0.048
North Yorkshire 1, UK	0.90 ± 0.17	0.94 ± 0.15	0.96	0.87
Northamptonshire 1, UK	0.59 ± 0.05	0.28 ± 0.08	0.48	0.029
Essex 1, UK	0.62 ± 0.07	0.37 ± 0.07	0.60	0.073
Essex 2, UK	0.89 ± 0.10	0.42 ± 0.09	0.47	0.027
Norfolk 1, UK	1.94 ± 0.44	0.61 ± 0.003	0.31	0.027
Devon 1, UK	4.97 ± 0.23	0.95 ± 0.16	0.25	0.00014
Leicestershire 1, UK	5.67 ± 0.43	1.33 ± 0.09	0.23	0.00058
Leicestershire 2, UK	4.71 ± 0.33	1.06 ± 0.02	0.23	0.00041
Derbyshire, UK	1.23 ± 0.08	0.50 ± 0.17	0.41	0.016
Lithuania 1	1.51 ± 0.06	1.35 ± 0.02	0.89	0.064
Lithuania 2	0.65 ± 0.12	1.55 ± 0.01	2.38	0.0018
Suffolk 1, UK	0.67 ± 0.05	0.79 ± 0.09	1.17	0.32
Suffolk 3 UK	1.02 ± 0.18	0.50 ± 0.04	0.49	0.048
Bulgaria 2	1.13 ± 0.17	0.69 ± 0.22	0.61	0.19
Bulgaria 3	1.17 ± 0.18	0.78 ± 0.11	0.67	0.14
Cambridgeshire 1, UK	2.38 ± 0.40	1.53 ± 0.21	0.64	0.13
Norfolk 2, UK	0.93 ± 0.06	0.60 ± 0.05	0.65	0.020
Northamptonshire 2, UK	0.65 ± 0.05	0.49 ± 0.002	0.78	0.018
North Yorkshire 2	2.68 ± 0.15	1.36 ± 0.08	0.51	0.003
Northern Ireland	0.61 ± 0.05	0.78 ± 0.17	1.27	0.17
North Yorkshire 4, UK	0.72 ± 0.22	0.67 ± 0.06	0.94	0.75
North Yorkshire 5, UK	0.42 ± 0.12	0.58 ± 0.07	1.38	0.12
Miltefosine APC 12	0.1 ± 0.03	67.0 ± 12.6	670	<0.001
Miltefosine APC 16	2.0 ± 0.20	56 ± 9.7	28	<0.001

All EC₅₀ values are given as average ± SEM (n = 3). Statistical difference between EC₅₀ values of the same sample against two strains was analysed using Student’s unpaired t-test.

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