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Figure 1

From: Model based development of tacrolimus dosing algorithm considering CYP3A5 genotypes and mycophenolate mofetil drug interaction in stable kidney transplant recipients

Figure 1

Prediction-corrected visual predictive check of population pharmacokinetic models. (a) TAC; (b) MPA; (c) MPAG; (d) AcMPAG. Closed circles represent observed concentrations. Solid red line represents median of observed concentrations and solid blue line represents 5th and 95th percentile of observed concentrations. Blue area represents 95% confidence interval of 5th and 95th percentile of predicted concentrations and red area, 95% confidence interval of the median of predicted concentrations. TAC, tacrolimus; MPA, mycophenolic acid; MPAG, MPA 7-O-glucuronide; AcMPAG, MPA acyl glucuronide

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