Figure 2
From: Lipophilic statins inhibit Zika virus production in Vero cells
Inhibition of infectious ZIKV production by lipophilic statins in Vero cells. (a) The lipophilic statins and chloroquine (reference drug) were used to simultaneously treat Vero cells infected with ZIKV (MOI of 0.01). Culture supernatants were collected at different timepoints, and viral production (TCID50) was measured by observation of cytopathic effects (CPE) after 96 hours. (b) Culture supernatants were also subjected to plaque assay in Vero cells. Percent infectivity was calculated by dividing the titer of the statin-treated setup by that of the untreated titer (PFU/mL). (c) Comparison of plaques formed in Vero cells at 10−5 dilution of supernatants are shown. *p < 0.01, Student’s t-test), and data presented are means ± SEM.
