Figure 4
From: CYLD dysregulation in pathogenesis of sporadic inclusion body myositis
Colocalization of CYLD with phosphorylated p62 in the muscle fibres of sIBM patients and TDP-43 TG mice. (a–t) Confocal microscopic analysis of localization of phosphorylated p62 (a,e,i,m,q) and CYLD (b,f,j,n,r) in muscles of patients with sIBM (a–d) or dermatomyositis (e–h), healthy control (i–l), and TDP-43 TG (m–p) or NTG mice (q–t). Nuclei were stained with DAPI. Merged images are presented in (d,h,l,p,t). Scale bars = 50 μm. (u) Percentages of myofibres with colocalization of phosphorylated p62 and CYLD in each group. n = 3–15 per group. *P < 0.05; ***P < 0.001.
