Table 3 Multivariate analysis using different parameters.

From: Clinical significance of tumor-infiltrating lymphocytes and neutrophil-to-lymphocyte ratio in patients with stage III colon cancer who underwent surgery followed by FOLFOX chemotherapy

 

Model1

Model 2

Hazard Ratio (CI)

P value

Hazard Ratio (CI)

P value

Operation time (min)

<300 vs. ≥300

2.4 (1–5.6)

0.043

  

Complications

No vs. Yes

  

2.2 (0.9–5.4)

0.075

LNR

<0.103 vs. ≥0.103

    

Stage

IIIC

1

0.026

1

0.023

IIIB

0.3 (0.1–0.7)

0.009

0.3 (0.1–0.7)

0.007

IIIA

0.2 (0–2.3)

0.243

0.3 (0–2.8)

0.325

TILs

High vs. Low

2.5 (1–5.9)

0.032

  

TILs and NLR

High TILs and low NLR vs. others

  

4.1 (1.1–14.2)

0.025

C-index

(95% Confidence Interval)

0.717(0.604–0.831)

0.737(0.623–0.850)

AIC

 

229.221

226.289

  1. Abbreviations; LNR: Lymph node ratio; TILs: Tumor infiltrating lymphocytes; NLR: Neutrophil to lymphocytes ratio.
  2. C-index: Harrell’s concordance index; AIC: Akaike information criterion.
  3. Factors with p value less than 0.1 in univariate analysis were entered into multivariate analysis.
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