Table 2 Number, percentage and expression of cytokines by dendritic cells of healthy controls and untreated HIV-infected patients.

From: Antiretroviral therapy partially improves the abnormalities of dendritic cells and lymphoid and myeloid regulatory populations in recently infected HIV patients

 

Healthy controls (n = 20)

Naïve patients with detectable HIV load (n = 20).

Overall (n = 20)

HIV infection, recent (n = 10)

HIV infection, chronic (n = 10)

mDC/mm3

39 (22–57)

81 (64–114)***

101 (70–173)**

79 (61–90)**

mDC (percentage of leukocytes)

0·7 (0.4–1.2)

1·6 (1·4–1·6)***

1·5 (1·3–1·7)**

1·6 (1·4–1·7)**

mDC expressing IL-12 (percentage of mDC)

0·6 (0·3–1·2)

12·5 (5·2–81·3)***

12·5 (5·2–50·0)***

11·9 (3·5–97·7)***

pDC/mm3

59 (21–108)

95 (80–169)*

94 (62–195)*

97 (80–137)*

pDC (percentage of leukocytes)

1·1 (0·4–1·6)

2·1 (1·7–2·4)***

2·1 (1·3–2·3)*

2·4 (1·7–2·6)**

pDC expressing IFN-α (percentage of pDC)

0·7 (0·3–1·1)

21·7 (14·2–26·0)***

22·6 (15·4–28·5)***

20·3 (9·6–22·9)***

  1. Abbreviations: mDC: Myeloid dendritic cells; pDC: Plasmocytoid dendritic cells; IL-12: interleukin 12; IFN-α: interpheron alpha.
  2. Data are provided as absolute number (percentage) or as median (interquartile range).
  3. HIV-infected patients vs healthy controls: *p < 0·05, **p < 0·01, ***p < 0·001.
  4. Patients with recent vs chronic infection: ‡p < 0·05, ‡‡p < 0·01, ‡‡‡p < 0·001.
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