Figure 5 | Scientific Reports

Figure 5

From: M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera

Figure 5

Muscarinic receptors regulate i-Extract mediated increase in KLK8 and MAP2 expression. M1 agonist (mAChR- Ag) inhibited SC mediated decrease and caused up-regulation while antagonist (mAChR- Ant) eliminated i-E mediated increase and caused down-regulation of (A) KLK8 mRNA and (B) KLK8 protein and (C) MAP2c protein in cerebral cortex and hippocampus. Column chart represents RDV (IDV of KLK8/GAPDH; IDV of KLK8/β-actin; IDV of MAP2c/β-Actin). Letters indicate statistical groups by FDR (p ≤ 0.05). Treatments sharing letter (within brain region) do not significantly differ.

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