Figure 4 | Scientific Reports

Figure 4

From: A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma

Figure 4

Gene set enrichment analysis (GSEA) and IPA pathway analysis of consensus AK4-AK1 PRECOG gene signature. GSEA plot of KOBAYASHI_EGFR_SIGNALING_24HR_DN gene set (a) and SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 gene set (b) in consensus AK4-AK1 PRECOG signature. (c) IPA Canonical pathway analysis of AK4-AK1 PRECOG gene signatures identifies altered metabolic pathways in lung adenocarcinoma patients. (d) IPA Upstream analysis of AK4-AK1 PRECOG gene signatures predicts activation or inhibition status of transcription regulators in lung adenocarcinomas. Transcription factors with activation Z-scoreā€‰ā‰„ā€‰2 or ā‰¤ āˆ’2 were predicted to be activated or inhibited respectively.

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