Figure 2
From: Early induction of C/EBPβ expression as a potential marker of steroid responsive colitis
Hydrocortisone intervention significantly improves histological colitis score in T. muris infected mice at day 45 p.i. (H&E, scale bar = 200 μm). (A) Normal colonic tissue in naïve mice. (B,C) Luminal and mucosal helminths and transmural colonic inflammatory changes were seen post T. muris infection in AKR/J mice. A reduction of muscle layer oedema, (double headed arrows) accompanied by a reduction in submucosal oedema and crypt hyperplasia was identified following steroid treatment of infected mice (C). (D) The histological assessment of mucosal architecture, ulceration, crypt abscesses, goblet cell depletion, cellular infiltration and tissue oedema was quantified. A significant reduction in colitis severity was seen following steroid treatment. Data represented as mean +/− SD, representative of two independent experiments, n = 5 per group.
