Table 2 Recoil retention of ²¹³Bi in the tumour tissue at 1 and 7 days after intratumoural injection of ²²⁵Ac encapsulated in polymersomes with a diameter of either 100 nm or 200 nm.

Organ 1 day p.i.	Blood		Tumour		Kidney
Organ 1 day p.i.	100 nm	200 nm	100 nm	200 nm	100 nm	200 nm
\({A}_{{213}_{Bi}}(t=0)\) (% ID/g)	1.2 ± 0.1	1.5 ± 1.4	122 ± 57	318 ± 111	23.0 ± 5.4	17 ± 7
\({A}_{{213}_{Bi}}(t=eq)\) (% ID/g)	0.05 ± 0.01	0.02 ± 0.01	212 ± 100	386 ± 154	0.87 ± 0.09	0.8 ± 0.4
Ratio	26 ± 8	58 ± 34	0.58 ± 0.06	0.87 ± 0.04	26 ± 6	23 ± 5
7 days p.i.	100 nm	200 nm	100 nm	200 nm	100 nm	200 nm
\({A}_{{213}_{Bi}}(t=0)\) (% ID/g)	0.9 ± 0.4	1.8 ± 0.9	146 ± 96	285 ± 75	15 ± 6	9 ± 4
\({A}_{{213}_{Bi}}(t=eq)\) (% ID/g)	0.01 ± 0.01	0.3 ± 0.4	269 ± 224	320 ± 116	0.9 ± 0.5	0.8 ± 0.5
Ratio	70 ± 40	30 ± 36	0.59 ± 0.12	0.91 ± 0.10	19 ± 10	12 ± 5

The numbers represent the ratio of the \({A}_{{213}_{Bi}}(t)\)_, the ²¹³Bi activity at time t = 0 of sacrifice, to ²²⁵Ac (t = eq), the ²¹³Bi activity in equilibrium with ²²⁵Ac, calculated as \(Ratio={A}_{{213}_{Bi}}(t=0)/{A}_{{213}_{Bi}}(t=eq)\). The uncertainty corresponds to standard deviations based on three mice per polymersome diameter and time point.

Quick links

Search