Table 5 RRs of second primary cancers (SPCs) in survivors of vulvar/vaginal cancer and other cancers.
Cancer site | After vulvar/vaginal cancer | After other cancers | ||||
---|---|---|---|---|---|---|
SPCs | RRb | 95% CIc | SPCs | RR | 95% CI | |
Upper aerodigestive tract | 26 | 2.26 | 1.54–3.32 | 14 | 0.33 | 0.20–0.56 |
Salivary gland | 1 | 0.58 | 0.08–4.12 | 4 | 0.72 | 0.27–1.91 |
Esophagus | 7 | 1.23 | 0.59–2.58 | 0 | — | — |
Stomach | 28 | 0.85 | 0.59–1.23 | 15 | 0.38 | 0.23–0.63 |
Small intestine | 7 | 1.80 | 0.86–3.78 | 0 | — | — |
Colorectum | 119 | 1.02 | 0.85–1.22 | 136 | 0.65 | 0.55–0.77 |
Anus | 26 | 10.31 | 7.01–15.16 | 8 | 2.31 | 1.16–4.63 |
Liver | 28 | 0.87 | 0.60–1.26 | 5 | 0.37 | 0.15–0.88 |
Pancreas | 26 | 0.91 | 0.62–1.33 | 2 | 0.17 | 0.04–0.68 |
Nose | 1 | 0.80 | 0.11–5.71 | 0 | — | — |
Lung | 81 | 1.81 | 1.45–2.25 | 9 | 0.22 | 0.11–0.41 |
Breast | 173 | 0.92 | 0.79–1.06 | 226 | 0.73 | 0.64–0.83 |
Cervix | 34 | 2.38 | 1.70–3.33 | 170 | 4.20 | 3.61–4.89 |
Endometrium | 37 | 0.82 | 0.59–1.13 | 136 | 1.52 | 1.29–1.80 |
Uterus, unspecified | 3 | 0.67 | 0.22–2.07 | 14 | 2.13 | 1.26–3.60 |
Ovary | 24 | 0.73 | 0.49–1.08 | 51 | 1.31 | 0.99–1.72 |
Vulvar/vaginal | 87 | 9.03 | 7.31–11.15 | |||
Kidney | 28 | 1.34 | 0.92–1.94 | 11 | 0.27 | 0.15–0.49 |
Urinary bladder | 45 | 1.82 | 1.36–2.44 | 38 | 0.40 | 0.29–0.54 |
Melanoma | 23 | 0.99 | 0.66–1.49 | 34 | 0.50 | 0.35–0.69 |
Skin | 59 | 1.19 | 0.92–1.54 | 66 | 0.66 | 0.52–0.85 |
Eye | 4 | 2.15 | 0.80–5.72 | 2 | 0.33 | 0.08–1.30 |
Nervous system | 17 | 0.88 | 0.55–1.41 | 17 | 0.45 | 0.28–0.73 |
Thyroid gland | 8 | 1.17 | 0.58–2.34 | 6 | 0.34 | 0.15–0.75 |
Endocrine glands | 12 | 0.83 | 0.47–1.46 | 29 | 0.71 | 0.50–1.03 |
Bone | 1 | 0.83 | 0.47–1.46 | 2 | 0.76 | 0.19–3.04 |
Connective tissue | 17 | 3.64 | 2.26–5.86 | 6 | 0.56 | 0.25–1.24 |
Non-Hodgkin lymphoma | 26 | 1.04 | 0.71–1.53 | 16 | 0.40 | 0.24–0.65 |
Hodgkin lymphoma | 4 | 1.62 | 0.61–4.33 | 5 | 0.83 | 0.35–2.00 |
Myeloma | 7 | 0.55 | 0.26–1.15 | 6 | 0.39 | 0.18–0.88 |
Leukemia | 24 | 1.02 | 0.68–1.52 | 13 | 0.36 | 0.21–0.63 |
CUPa | 45 | 1.20 | 0.89–1.60 | 11 | 0.59 | 0.33–1.07 |
All (excluding vulvar/vaginal) | 941 | 1.28 | 1.20–1.37 | 1052 | 0.75 | 0.70–0.80 |