Table 5 RRs of second primary cancers (SPCs) in survivors of vulvar/vaginal cancer and other cancers.

From: Familial Clustering, Second Primary Cancers and Causes of Death in Penile, Vulvar and Vaginal Cancers

Cancer site

After vulvar/vaginal cancer

After other cancers

SPCs

RRb

95% CIc

SPCs

RR

95% CI

Upper aerodigestive tract

26

2.26

1.54–3.32

14

0.33

0.20–0.56

Salivary gland

1

0.58

0.08–4.12

4

0.72

0.27–1.91

Esophagus

7

1.23

0.59–2.58

0

Stomach

28

0.85

0.59–1.23

15

0.38

0.23–0.63

Small intestine

7

1.80

0.86–3.78

0

Colorectum

119

1.02

0.85–1.22

136

0.65

0.55–0.77

Anus

26

10.31

7.01–15.16

8

2.31

1.16–4.63

Liver

28

0.87

0.60–1.26

5

0.37

0.15–0.88

Pancreas

26

0.91

0.62–1.33

2

0.17

0.04–0.68

Nose

1

0.80

0.11–5.71

0

Lung

81

1.81

1.45–2.25

9

0.22

0.11–0.41

Breast

173

0.92

0.79–1.06

226

0.73

0.64–0.83

Cervix

34

2.38

1.70–3.33

170

4.20

3.61–4.89

Endometrium

37

0.82

0.59–1.13

136

1.52

1.29–1.80

Uterus, unspecified

3

0.67

0.22–2.07

14

2.13

1.26–3.60

Ovary

24

0.73

0.49–1.08

51

1.31

0.99–1.72

Vulvar/vaginal

87

9.03

7.31–11.15

   

Kidney

28

1.34

0.92–1.94

11

0.27

0.15–0.49

Urinary bladder

45

1.82

1.36–2.44

38

0.40

0.29–0.54

Melanoma

23

0.99

0.66–1.49

34

0.50

0.35–0.69

Skin

59

1.19

0.92–1.54

66

0.66

0.52–0.85

Eye

4

2.15

0.80–5.72

2

0.33

0.08–1.30

Nervous system

17

0.88

0.55–1.41

17

0.45

0.28–0.73

Thyroid gland

8

1.17

0.58–2.34

6

0.34

0.15–0.75

Endocrine glands

12

0.83

0.47–1.46

29

0.71

0.50–1.03

Bone

1

0.83

0.47–1.46

2

0.76

0.19–3.04

Connective tissue

17

3.64

2.26–5.86

6

0.56

0.25–1.24

Non-Hodgkin lymphoma

26

1.04

0.71–1.53

16

0.40

0.24–0.65

Hodgkin lymphoma

4

1.62

0.61–4.33

5

0.83

0.35–2.00

Myeloma

7

0.55

0.26–1.15

6

0.39

0.18–0.88

Leukemia

24

1.02

0.68–1.52

13

0.36

0.21–0.63

CUPa

45

1.20

0.89–1.60

11

0.59

0.33–1.07

All (excluding vulvar/vaginal)

941

1.28

1.20–1.37

1052

0.75

0.70–0.80

  1. CUPa = cancer of unknown primary. RRb = relative risk. 95% CIc = 95% confidence interval, bold font indicates that the lower limit of 95% CI does not include 1.00.