Table 2 Renal function parameters of baseline, at the time of AKI occurrence and CRRT initiation.

From: Optimal timing of initiating continuous renal replacement therapy in septic shock patients with acute kidney injury

 

Survivors

n = 78 (49.4%)

Non-survivors

n = 80 (50.6%)

P value

At acute kidney injury occurrence

   Lactate (mmol/L)

4.9 (2.8, 9.8)

7.0 (3.7, 12.6)

0.113

   BUN (mg/dL)

50.0 (30.5, 70.6)

40.5 (26.2, 57.5)

0.047

   Creatinine (mg/dL)

2.54 (1.54, 3.66)

1.88 (1.27, 2.88)

0.003

   Potassium (mmol/L)

4.7 (1.0, 5.8)

4.4 (3.7, 5.1)

0.024

   Urine output (ml/day)

1,493 (505, 2,140)

1,114 (467, 2,487)

0.698

   pH

7.295 (7.236, 7.389)

7.299 (7.209, 7.395)

0.963

   GFR (ml/min/1.73 m2¥)

24 (16, 39)

31 (19, 53)

0.020

   GFR (ml/min/1.73 m2€)

23 (15, 42)

32 (18, 57)

0.015

At ICU admission

   Lactate (mmol/L)

3.4 (2.2, 5.6)

9.7 (4.4, 15.3)

<0.001

   BUN (mg/dL)

44.0 (31.2, 65.7)

44.5 (31.9, 63.7)

0.836

   Creatinine (mg/dL)

2.44 (1.45, 3.34)

2.34 (1.55, 3.07)

0.766

   Potassium (mmol/L)

4.3 (3.6, 5.1)

4.3 (3.7, 5.0)

1.000

Urine output (ml/day)

585 (196, 1,381)

520 (188, 1,070)

0.321

pH

7.379 (7.306, 7.430)

7.300 (7.251, 7.374)

<0.001

At CRRT initiation

   Lactate (mmol/L)

4.3 (2.6, 8.9)

7.5 (4.2, 15.5)

0.001

   NGAL (ng/mL)

1,004 (465, 1,695)

820 (367, 2,083)

0.488

   Cystatin C (mg/L)

2.76 (1.87, 3.89)

2.89 (2.04, 3.93)

0.640

   GFR (ml/min/1.73 m2≠)

14 (8, 28)

14 (8, 25)

0.829

Interval time from AKI to CRRT initiation (hours)

9 (6, 14)

26 (11, 66)

<0.001

CRRT duration (hours)

78 (52, 146)

67 (31, 212)

0.607

  1. Values are expressed as n(%) or median(interquartile range) unless otherwise indicated; ¥Estimated by MDRD equation; €Estimated by CKD-EPI creatinine equation; ≠Estimated by CKD-EPI cystatin C equation.
  2. AKI, Acute Kidney Injury; CRRT, continuous renal replacement therapy; BUN, blood urea nitrogen; GFR, Glomerular Filtration Rate; NGAL, Neutrophil Gelatinase-Associated Lipocalin; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration.
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