Figure 9

Tail flick response test in wild type, H304R/+, and H304R/R mutant mice at 3 months of age. The graph shows the latency of tail withdrawal (seconds) to pain stimulus in male (A) and female (B) mice. The box plot represents the 25th to 75th percentile of the data points with a middle line at the median and the whiskers ranging from the smallest to the largest value. The tail flick data was compared between the wild type (in dark gray), H304R/+ (in light gray), and H304R/R (in white) mice using the Kruskal-Wallis ANOVA test (*p < 0.05).