Figure 1
From: Regulation of PDE5 expression in human aorta and thoracic aortic aneurysms
PDE5 expression in control aortas and in TAAs samples. Quantitative RT-PCR showing PDE5 mRNA levels downregulation in TAV, BAV and Marfan syndrome TAA samples compared to control aortas. Normalization of PDE5 mRNA levels was referred to SMA (A) and GAPDH (B) mRNA levels. Data were normalized to the mean of control values, set to 1.0. (C) Representative images of PDE5 expression in the aortic medial layer of control, Marfan, BAV and TAV samples by immunoistochemistry. Bars = 50 μm (D) Quantitative RT-PCR of PDE5A1, A2 and A3 isoforms in controls and TAA specimens. Bars represent ± SD. **p < 0.01 on three experiments.
