Figure 2 | Scientific Reports

Figure 2

From: Catalytically Impaired TYK2 Variants are Protective Against Childhood- and Adult-Onset Systemic Lupus Erythematosus in Mexicans

Figure 2

Multifactor dimensionality reduction models of the TYK2 and IRF5 interaction. Dark gray columns indicate controls, and light gray columns indicate cases, with the numbers of controls and cases noted at the bottom of each column. (A) The best single-locus model for IRF5 rs2070197/C. (B) The best two-locus model, including the TYK2 variant rs280500/G and IRF5 variant rs2070197/C. (C) The three-locus model, showing interaction between the TYK2 variant rs280500/G and the IRF5 variants rs2004640/G and rs2070197/C.

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