Figure 5 | Scientific Reports

Figure 5

From: The Low Toxicity of Graphene Quantum Dots is Reflected by Marginal Gene Expression Changes of Primary Human Hematopoietic Stem Cells

Figure 5

Sketch of the design and the result of the gene expression experiment. The transcriptome of the CD34+ cells was measured before and after exposure of the cells to the two experimental conditions. The modified gene expressions are sorted according to the ratio of their amplification in the presence vs. the absence of the GQDs in the culture. The expression of 5012 genes was changed under both culture conditions, while the expression of 485 genes was only changed in the presence of GQDs and the expression of 686 genes only differed when the CD34+ cells were cultivated without GQDs. (b) Allocation of the changes to 24, 5 and 3 affected signaling pathways, respectively (inset) and the -log p - values of the 8 pathways with significant response to the GQDs (main figure). Also shown is the effect on the pathways DNA replication, metabolic and ribosome biogenesis.

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