Figure 5

In vivo changes in blood glucose level (BGL) were measured by the administration with ATEC or DEHP. (A–F) Various doses of 2,000 (A–D), 400, 40 and 4 (C–F) mg/kg ATEC (A–C,E) or DEHP (A,B,D,F) and saline in control group were administered into mice by oral gavage for 5 consecutive days (A,C,D). Experiments in (C,D) were simultaneously performed with the same saline-administered control group. An additional single dose was applied to the same mice 7 days after the last administration (B,E,F). Experiments in (E,F) were simultaneously performed with the same saline-administered control group. BGL was measured in blood collected at 15, 30, 60, 90 and 120 min from each mouse which were fasted for 18 h and injected with 20% D-glucose solution. Changes in BGL were represented with line graph. Data in line graph represent mean ± SED (n = 4). *p < 0.05; **p < 0.01, significant difference as compared to control group at each time point.