Figure 1 | Scientific Reports

Figure 1

From: Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations

Figure 1

Histologic and immunohistochemical features of patients’ tumors and corresponding PDX at different in vivo passages. OS sections were stained with hematoxylin and eosin (H&E) or with antibodies against OS biomarkers SATB2 and PGP. PDXs closely resembles patient’s tumor, including the production of neoplastic bone and the presence of anaplastic cells. SATB2 and PGP expression of PDX mirrored that of patient’s tumor. EW sections were stained with H&E or with antibodies against EW biomarkers CD99 and CAV-1. EW PDXs consist of small round cell sheets, closely packed and without matrix, resembling patient’s tumors. CD99 and CAV-1 expression of PDX mirrored that of patient’s tumor. Bar: 50 μm.

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