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Figure 2

From: Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations

Figure 2

Unsupervised clustering using all (40 K) genes and all specimens (A). Correlation between OS (B) and EW (C) samples calculated using the whole gene expression profile obtained from microarray analysis. Correlation indexes (Pearson’s r) was used to perform the hierarchical clustering of samples (Euclidean distance). Abbreviations: PC, primary in vitro culture; F0, patient’s specimen; F1, PDX at first in vivo passage; F6, PDX at sixth in vivo passage.

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