Table 1 Temperature effect on NET indices of the median sensory axons for both normal controls (NC) and IEM patients (IEM).

From: Anomalous enhancement of resurgent Na+ currents at high temperatures by SCN9A mutations underlies the episodic heat-enhanced pain in inherited erythromelalgia

 

Baseline

Cooling

NC (n = 10)

IEM (n = 4)

p*

NC (n = 10)

IEM (n = 4)

p**

Age (year)

27.7 ± 0.7

27.3 ± 3.8

1.000

27.7 ± 0.7

27.3 ± 3.8

1.000

Temperature (°C)

36.2 ± 0.3

36 ± 0.4

0.831

25.6 ± 1.4

24.4 ± 1.2

0.887

Strengthduration curve

Rheobase (mA)

1.81 ± 0.18

1.41 ± 0.23

0.724

1.92 ± 0.14

1.62 ± 0.2

0.525

SDTC (ms)

0.554 ± 0.019

0.737 ± 0.063

0.020

0.558 ± 0.013

0.66 ± 0.043

0.056

Threshold Electrotonus (TE)

TEd(1020ms) (%)

60.1 ± 2.1

59.1 ± 2.2

0.525

51.1 ± 2.2

57.4 ± 1.6

0.179

TEd(90100ms) (%)

56.8 ± 2.2

50.6 ± 3.2

0.179

56.2 ± 2

49.5 ± 1.8

0.056

TEh(1020ms) (%)

−82.3 ± 3.2

−83.8 ± 3.1

0.621

−79 ± 3.1

−82.6 ± 4

0.437

TE h(90 100ms) (%)

−143.9 ± 8.2

−118.6 ± 8.8

0.104

−144.1 ± 7

−131.8 ± 3.6

0.358

TE h99ms (%)

−144.8 ± 8.2

−116.8 ± 9.2

0.138

−145.7 ± 6.9

−131.4 ± 3.4

0.358

TEh,slope (101140) (%/ms)

2.32 ± 0.13

2.32 ± 0.17

1.000

2.05 ± 0.1

2.42 ± 0.11

0.104

TEh,overshoot (%)

19.9 ± 1.8

23.6 ± 3.1

0.289

21.3 ± 2.1

25.7 ± 2.4

0.289

Recovery cycle

Relative refractory period (ms)

3.97 ± 0.37

4.91 ± 0.47

0.138

5.91 ± 0.79

6.61 ± 1.17

0.933

Refractoriness (%)

49.3 ± 17.1

136.3 ± 79.4

0.138

113.5 ± 30.9

98.7 ± 66.3

0.915

Superexcitability (%)

−23.7 ± 1.9

−15.5 ± 1.6

0.040

−18.7 ± 2.4

−11.8 ± 5.6

0.358

Subexcitability (%)

10 ± 0.7

10.4 ± 0.5

0.438

8.2 ± 0.7

9.1 ± 0.5

0.437

Current–threshold (I/V) curve

Hyperpolarizing IV slope

0.348 ± 0.031

0.324 ± 0.042

0.832

0.283 ± 0.033

0.251 ± 0.021

0.944

IV80%(%)

−290.7 ± 10.2

−236.5 ± 14.2

0.020

−320.6 ± 8.6

−301 ± 17.1

0.437

IV100%(%)

−352.2 ± 12.8

−301.5 ± 21.3

0.077

−397.2 ± 11

−382.6 ± 23.6

0.525

  1. This table made by conducting Mann–Whitney test, and the distribution was presented by mean ± S.E.M.
  2. *Compared to NC at normal temperature.
  3. **Compared to NC at cooling.