Table 3 The kinetic parameters for the wild type (WT) and IEM channel models.

From: Anomalous enhancement of resurgent Na+ currents at high temperatures by SCN9A mutations underlies the episodic heat-enhanced pain in inherited erythromelalgia

 

WT

IEM

k 0

(ms−1, at 25 °C)

k 1

(mV)

Q10

k 0

(ms−1, at 25 °C)

k 1

(mV)

Q10

α

100

0.08

2.1

500

0.08

2.1

β

0.55

−0.01

2.1

4

−0.01

2.1

γ

40

0.01

2.1

40

0.01

2.1

δ

2

−0.01

2.1

2

−0.01

2.1

Coff

0.5

 

3.2

0.5

 

3.2

Con

0.1

 

3.2

0.1

 

3.2

Ooff

0.004

 

3.2

0.004

 

3.2

Oon

2.5

 

3.2

2.5

 

3.2

O1O2

0.12

0.057

2

0.12

0.057

2.6

O2O1

0.001

−0.095

2

0.001

−0.095

2.6

O2I2

0.5

0.04

2

0.3

0.04

3.3

I2O2

0.06

−0.03

2

0.07

−0.03

3.3

I1I2

0.002

0.01

2.6

0.001

0.01

2.6

I2I1

0.2

−0.038

2.6

0.12

−0.038

2.6

  1. All transition rates are expressed as k0·ek1*E·Q10 (T–T0)/10, where k0 is the transition rate at 0 mV, k1 is the voltage dependence constant in mV−1, E is membrane potential in mV, Q10 is the temperature coefficient, and T is temperature in °C (with T0 at 25 °C). The basic kinetic parameters at room temperature are the same as those reported previously21, with slight changes in k1 of δ and k0 of I2O2 and O2I2 of the WT and IEM channels for better simulation of all of the findings in different temperatures. The main differences between the kinetics of WT and IEM channels are in k0 of α, β, O2I2, I2O2, I1I2 and I2I1 and the temperature dependence of transition between states O2 and I2 (bold letters).
Back to article page